HORDB

ID: hor005699
Uniprot ID: P42579
Protein name: Sodium-influx-stimulating peptide
Gene name: SIS
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: NA
Source: animal
Expression: Expressed by the yellow cells, peptidergic (neuroendocrine) neurons of the central nervous system.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: NA

Sequence: SRTQSRFASYELMGTEGTECVTTKTISQICYQCATRHEDSFVQVYQECCKKEMGLREYCEEIYTELPIRSGLWQPNK
Length: 77
Propeptide: MLSSVALRYLLVLSLAFLAVVTSSRTQSRFASYELMGTEGTECVTTKTISQICYQCATRHEDSFVQVYQECCKKEMGLREYCEEIYTELPIRSGLWQPNK
Signal peptide: MLSSVALRYLLVLSLAFLAVVTS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates integumental Na+?uptake. Controls the activity of sodium pumps in the integument, pericardium, ureter and nephridial gland.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005699_AF2.pdb

hor005699_ESM.pdb

Mass:	1036992	Formula:	C387H604N106O126S8
Absent amino acids:		Common amino acids:	E
pI:	5.08	Basic residues:	10
Polar residues:	30	Hydrophobic residues:	16
Hydrophobicity:	-68.96	Boman Index:	-18029
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	54.42
Instability Index:	6781.3	Extinction Coefficient cystines:	13325
Absorbance 280nm:	175.33

PubMed ID: 8344306
Title: cDNA cloning of the sodium-influx-stimulating peptide in the mollusc, Lymnaea stagnalis.
PubMed ID: 8234026
Title: The sodium influx stimulating peptide of the pulmonate freshwater snail Lymnaea stagnalis.